What does HackerNews think of SponsorBlock?
Skip YouTube video sponsors (browser extension)
There's clients for many other platforms, even traditionally locked down ones like iOS Safari etc.
At home, I have AdGuardHome installed in a VM acting as my home network's DNS. It's pretty effective and is an alternative to PiHole. This is a first-tier filter I have while at home for all my devices. https://github.com/AdguardTeam/AdGuardHome/
On the web browser, I have the AdGuard Firefox extension. https://adguard.com/en/adguard-browser-extension/firefox/ove...
For my mobile phone, it's a little obtuse but relatively straightforward. I have a non-rooted Android phone. I've installed AdGuard for Android there as well. The way it works is it runs a local VPN on my phone, so all device traffic goes through a localhost proxy, which filters the DNS and unencrypted TCP traffic. For HTTPS filtering, it installs a local TLS CA to perform re-signing of websites (you can configure it to ignore EV certificates, as I have, which are more common with online banks and more secure sites). It works pretty well with exception to apps that have built-in ad platforms like Instagram. It blocks 100% of ads in apps like Wunderground, Reddit, and Firefox. https://adguard.com/en/adguard-android/overview.html. There's also an iOS version of the app on their website.
I have a Google Play Music subscription which comes with YouTube Premium. However, more and more YouTubers are diversifying their revenue, and have gone to completely sponsored videos with embedded ads. For sponsored clips in YouTube, SponsorBlock extension: https://github.com/ajayyy/SponsorBlock
Decentraleyes [sic] is another extension that I use primarily on my phone, but also at work. It allows the web browser to use local versions of CSS/JS frameworks and fonts that would otherwise have to load from CDNs that track your requests. Things like jQuery, Bootstrap, AngularJS, FontAwesome, etc. are all loaded from local copies through this extension. This benefits the user by saving bandwidth and page load time as well as stopping unwanted tracking from the remote party. https://addons.mozilla.org/en-US/firefox/addon/decentraleyes...
Don't Fuck With Paste. This extension prevents websites from disabling pasting in form fields. Extremely useful when you are using a password manager to enter form data or just copying and pasting from another location. Websites that break paste are just as bad as websites that serve ads in my book. https://addons.mozilla.org/en-US/firefox/addon/don-t-fuck-wi... (it's also available for Chrome).
If you know someone or you yourself actually still use Facebook, I also highly recommend Social Fixer. Not only does it block Facebook ads and other page elements, but it lets you keep track of other events like who unfriends you. It has a lot of options and I've been using it for years. https://socialfixer.com/
Worth checking out are NoScript extension, PiHole, and UBlock Origin. I don't use these but I've heard good things about them and everyone seems to recommend them.