Has anyone noticed 2-3 ads per YouTube video (especially midstream)? It’s getting ridiculous.

There’s got to be a stop to this madness.

Yeah it's called YouTube Premium. Think like a Netflix subscription but for YouTube. Google probably A/B tested different versions of YouTube to see which one generated more YouTube Premium subscribers. It turns out that the higher $$$-generating code (i.e. driving Premium subscriptions) is the one that bypasses Safari's adblocking engine.

Is there guaranteed no ads with Premium or do they still put ads in there? I mean some streaming services and of course the old paid cable TV did.

Guaranteed no ads injected by YT, but don't forget that already most popular YT content includes ads inside the video, as a small bit of informercial style content somewhere in the middle of the video.

On desktop there's the SponsorBlock extension, which skips them using a crowdsourced list of timestamps.

https://github.com/ajayyy/SponsorBlock