What does HackerNews think of cassowary?
Run Windows Applications on Linux as if they are native, Use linux applications to launch files files located in windows vm without needing to install applications on vm. With easy to use configuration GUI
My next system is going to be a lightweight Linux host with a pile of VMs and something like https://github.com/casualsnek/cassowary, with juicy enough hardware to make it feel like I'm only running one OS.
It's quite absurd, really, because while the Linux desktop environment is certainly good for novices and advanced Linux users, anyone that falls between those categories (and that's a lot of people!) will definitely struggle when they try to switch to Linux. You're either content with the default setup, or need to dive into the terminal at some point, and the fact commercial operating systems are making their UX worse than Linux would be impressive if it wasn't so disappointing.
For what it's worth, I've managed to get Fusion360 running on Manjaro with a script a friend linked me online. I can't remember where I got it from exactly, but it involved auto downloading a bunch of Wine requirements and then just running the setup.
If you're not interested in tweaking your system, feel free to skip over the rest of the comment. If you're willing to give it a go, I've got some experience with Windows stuff on Linux that you may be interested in.
I barely use Fusion360, but the few times I used it, it worked pretty well in Wine. Even had decent 3D acceleration, though you can probably get a lot better performance with more trickery (DXVK etc. to enhance the 3D acceleration for example). Lutris (https://lutris.net/) has an install script (https://lutris.net/games/autodesk-fusion-360/), I recommend you give it a try. Lutris can help enable performance tuning tricks for productivity software quite easily, even if it's originally developed for playing video games. Might work for you, or it might not; if it does, it might just cut down on more unnecessary reboots. If it doesn't, you'll at most lose the time it takes to download the installer and remove the failed installation.
As for the video conferencing, you might be interested in Cassowary (https://github.com/casualsnek/cassowary), a tool to run Windows executables in a Windows VM through RDP, with suspend/resume of the VM on demand to cut down on resources used when you're not using Windows. It requires a bit of setup, but the guide is quite comprehensive in my opinion. You can forward your webcam to the Windows VM through USB forwarding to get it to work with video, and modern RDP should just be an RDP stream so there shouldn't be too much quality loss. Even if the Cassowary setup doesn't work, you can probably use the VM anyway.