I notice this was written in 2016, but I wonder if the author's opinion has changed since dataclasses have been implemented in Python.
Python's async support also seems to be getting better. There's a flask clone called Quart (http://pgjones.gitlab.io/quart/) and an async postgres client (https://github.com/MagicStack/asyncpg). It works very similar to JavaScript, with async and await keywords. I think it should provide speed and comfort especially if you're a regular JavaScript user.