I'm a big fan of Scheme/CL but I find development in ClojureScript to be quite frustrating. If anyone has some solutions I'd LOVE to hear them; while es6 is great I'd still prefer a more lispy language.

My major gripe is with debugging, when I'm writing es6 it's really easy to set a breakpoint and modify a function half way through execution. Or half finish a program and then play around with completions in the REPL to explore a problem. Sometimes I'll be traversing a complex data structure and I'll write an empty loop with just a breakpoint. I can then run the code and work through things in a concrete state and once I've got things working bringing the code back into my codebase.

When I write in any compile-to-js language I always run into the same problem where once I'm in browser I have to go back to vanilla js and any advantage I may have gained is quickly erased by having to deal with transpiled code.

Additionally with libraries like lodash-fp and newer ES features (promises, fat arrows, const and let etc.) the clarity in vanilla JS code is approaching a reasonable level.