The last time I wrote any ClojureScript was over a year and a half ago. I played around with Reagent a bit and remember really liking it. I never used it for any serious projects or in anger though - how is the tooling and debugging experience? I would love to use ClojureScript for my front end work (since I always end up using React + ImmutableJS anyways) but developer ergonomics are really important to me.
Fighwheel and cljs-devtools (https://github.com/binaryage/cljs-devtools) makes working with ClojureScript very ergonomic. The regularity that re-frame brings (knowing where all data resides and exactly what can change it) makes it even nicer.