People keep saying not to use this, and I think that's pretty wrong-headed.
Sure, if you're going to do greenfield software development, and you don't absolutely need to kind of closeness to the metal (not just performance, but direct access) that C offers, then use something else (Rust, Zig, Go ... if you need to compile to native binaries, Java, C# & their myriad of variants if you don't).
But if you have to use C, to extend an existing project, use a specific library, or hook some other system... why not use Cello?
For sure, this is not a tight black-box abstraction, so you should strive to understand the semantics of how it works. Once you do though, it'll make your life a whole lot simpler.
Seems to me, Cello would be more for those C programmers that didn't want to try the various alternative languages that are now out, and happen to agree with its developer's interpretation of preferred higher level abstractions and what they should look like. The point of these alternative languages is to offer features that C doesn't have or to implement them in easier or clearer ways.