Spent a year with Guix and writing my own configuration. Definitely much easier to reason about using Lisp syntax over Googling what random function of the DSL you need in Nix, but I ultimately switched to Nix because of it's community and Darwin support. Nix has a large group of folks who just want a sane, declarative way to manage their environments, and to get back to what they were doing. I want to spend the least amount of time managing my tools and when running into problems with Guix, digging for answers or jumping into the REPL just took too long. Lots of devs in the Guix community seem motivated to build and contribute back, which is great if you're looking to spend your time doing that.

I now use Nix to share configuration between my Macbook Pro, NixOS Desktop, VMs in my home lab, etc. Both Guix and Nix are amazing once you've developed your configuration, I'll never go back. I do a simple "./bin/nixos-update" and "./bin/macos-update" and Nix takes care of the rest.

Occasionally I'll pull something upstream that borks my machine; rolling back is so trivial, I'll just check nixpkgs for Issues to see what's going on, where usually I'll find a 1-liner to fix it or I'll wait for the next release.

Links to my configs https://github.com/dustinlyons/guix-config https://github.com/dustinlyons/nixos-config