I don't normally use Python. When I see something that I'd like to install, and the docs say "written in Python", my heart sinks. I know I'll have to find out how to install multiple dependencies in various packaging systems, all of which will be incompatible (but surely much better) than my system package manager.
I find all of this ironic given that the main gripe people used to have against Common Lisp was "but how do I make a self-contained binary?". Somehow this was never required of Python.
If I provide an end user software to my client written in Python (so not a backend, not a lib...), I will compile it with nuitka (https://github.com/Nuitka/Nuitka) and hide the stack trace (https://www.bitecode.dev/p/why-and-how-to-hide-the-python-st...) to provide a stand alone executable.
This means the users don't have to know it's made with Python or install anything, and it just works.
However, Python is not like Go or Rust, and providing such an installer requires more work, so a huge part of the user base (which have a lot of non professional coders) don't have the skill, time or resources to do it.
And few people make the promotion of it.
I should write an article on that because really, nobody wants to setup python just to use a tool.
Do check out nuitka though, it's has great support for QT, numpy, advanced Python constructs and has a permissive learning curve. You may even get a up to a X4 perf boot.
Not cross compilation though.
There is a startup idea right there.