The smalltalk interface is really one of the cleanest interfaces ever created. Too bad the software stack hasn't been put together in a complete desktop even like a simple one such as TempleOS
There was a variant of Squeak that ran on bare metal: http://squeaknos.blogspot.com
There is the more recent CogNos/NopSys [1,2] "an evolution of the SqueakNOS project" "a Smalltalk virtual machine running on bare x86 hardware", but that project has also been inactive for several years.