Apart from Clojure (which is not LISP, really), I haven't seen end-user applications written in LISP dialects (I don't think emacs is end-user software). Scheme (and its PLT dialect Racket) was in academia for so long that it literally got "friend-zoned" and has little (read "no") use in the industry.
Then again, I expected to see more Common LISP around. Paul Graham really put it right, but I guess any leverage/advantage LISP had on other languages, it waned in the 90's (maybe Viaweb was one of the last projects done in LISP, and even that was translated later to other langs...)
I don't think s-expressions are _that_ problematic. The main issue with LISP's nowadays is lack of _momentum_. Java gained its momentum by Sun, after that it just keeps rolling in the industry and apparently, there's no stopping that. Python also has its momentum from the academia, what with all the great libraries and all. But one would expect to see some _major_ projects done entirely in LISP (and not a Trojan Horse LISP like Clojure), after that, it's only a matter of time for developers to become LISPers.
Of course, one could also claim that LISP actually _did_ have like half a century to prove itself, or gain momentum. After all, Golang and ruby are relatively new, but they eat LISP's lunch at launch of new apps.
I really appreciate things like this project. It's not enough, but what is?