Jarred

This is something between desktop and web, but you could use Chromium Embedded (http://code.google.com/p/chromiumembedded/). It uses GTK+ on Linux, Cocoa on Mac OS X, and it's own library on Windows (but it looks identical to Windows' UI elements).

zoobert

@Jarred. Thanks for sharing about the CEF project. I need to build a cross-platform GUI in Python if possible and wanted to use wxWidgets with the python binding. Now CEF seems really great: The possibility to make an HTML5-Javascript App and having also the opportunity to deploy it on a web-server is really exiting. I will have to evaluate it, seems really cool. Can you access files on the file system as a normal native application or do you have to write in a dedicated sandboxed area ?

feronull
Adobe Bracket(https://github.com/adobe/brackets/) are using it and they are editing files from the disk. From looking at the source of their implementation I think that this is how you access system functionality https://github.com/adobe/brackets-app/blob/master/src/win/ce...