I love Django and have been using it for many many years. Lately, however, I’ve been finding it increasingly difficult not to be annoyed by some aspects of the developer experience. For example I’d choose React + Typescript over Django templates any time of the day.
You could use Django just for the backend and have your frontend code be written in React+Typescript, no?
But that means throwing out a large part of Django and writing lots of "interconnect" code. At that point I think it's better to choose a different backend, one that will generate typed Typescript client code (or use Typescript on the server and some clever metaprogramming).
You can also just generate an Open API spec and use something like openapi-generators to produce typed client code for data fetching (https://github.com/OpenAPITools/openapi-generator)