Counterstrike represent! I'd love to see popularity breakdown of applications run by wine. What else do people use it for?

I can only speak for myself, but I use it for loading VST plugins in Linux.

How do you do this specifically? Do you use some kind of bridging software or do you make a shim for each plugin that loads Wine on the fly?

Yabridge [1] uses wine to seamlessly load VST plugins into a host. It pretty much just works.

[1] https://github.com/robbert-vdh/yabridge