This is a huge problem for Linux distributions. I've been thinking of trying to open source a project (it's a web application simulator) that we have internally, that is built using Javascript/NodeJS and Python/Flask. While the mechanics of slapping a GPLv3 license on the code we wanted to publish were fairly straightforward, severe problems arose when we wanted to package it for distribution with an OS like Debian. The application is a web app that uses both Node and Python, and the complexities packaging it were overwhelming. For now we planning on releasing it as a container image. I'm not fan of doing this, but it seemed like a solution we conceivably implement with the time and resources we had available to us.