I'm surprised this is the top slot right now. Troy, generally, puts out interesting info on security related news however this feels a bit minimal. Since the project has been around a number of years now, and it's not relegated to only a RPi I would have expected him to delve into things a bit more. Pi-hole will also break things. I think the common one I always heard from users on my network at home were that Google click-thrus for products always fail. But... Don't deploy it on an RPi. It's not worth the inconvenience of maintaining another entire device for a network service. There's an actively maintained container I'd recommend, or it's very easy to deploy as a VM. Troy also didn't hit on anything like DoH or DoT, surprisingly.
Container link: https://hub.docker.com/r/pihole/pihole/
Edit: word
The simplest approach is to use a hosts file: https://someonewhocares.org/hosts/
That doesn't work the same as pihole. PiHole blocks ads on ALL devices on your network. Your computer, your laptop, your phone, your kids kindle, etc. As long as they are on your network, they are protected (and browsing web pages on an older phone, things are much faster)
Yup, that's a downside. The advantage is that it's much simpler and will also work when you're not on your home network.
How do I edit the hosts file on my iPhone?